First, Do No Harm: Critical Appraisal of Protein Restriction for Diabetic Kidney Disease

Low-protein diets have been recommended as diet therapy for the management of chronic kidney disease; however, its effect on disease has not scientifically proven. Although several studies reported significantly more favorable results with low-protein than normal-protein diet, renal protective effects are still unclear in diabetic patients disease. Moreover, some that extremely may increase risk mortality. Thus, this paper describes effectiveness and safety by reviewing historical background different were critically examined studies.